David Duchovny as Denise Bryson – Twin Peaks (1990-91, 2017)
“Coop… I may wear a dress, but I still put my panties on one leg at a time, if you know what I mean.”
Before starring in the cult hit X-Files in 1993, Duchovny played a former FBI agent named Denise Bryson, a transgender female. In the role, he had to learn how to mimic the mannerisms of women. He often jokingly says that in the role he had to use Nair on his legs, and continues doing so today.
Duchovny reprises the role of Denise in the 2017 follow-up of Twin Peaks.